We’ve waded through the sea of supplements so you don’t have to, testing products that promised everything short of making us look like Greek gods overnight. Some delivered, some didn’t, and some just made us really, really regular (if you catch my drift). So grab your favorite zero-calorie beverage, settle into that chair you’re hoping to need a smaller version of soon, and let’s dive into the wonderful world of GLP-1 supplements that won’t require a second mortgage!
What in the World is GLP-1 Anyway?
Before we start throwing money at Amazon, let’s take a quick science detour. GLP-1 (Glucagon-Like Peptide-1) is a hormone that your intestines release when food enters your system. It’s like your body’s natural “I’m full” signal, telling your brain to put down that third donut while slowing down digestion so you feel satisfied longer. It also helps your pancreas release insulin, which is great news for blood sugar control.
The supplements we’re looking at today aim to either boost your natural GLP-1 production or mimic its effects. They’re not the same as prescription GLP-1 medications (like Ozempic or Wegovy), but they’re trying their best to give you similar benefits without the prescription or the hefty price tag. Think of them as the understudy waiting in the wings – not quite the star of the show, but still capable of a decent performance!
The Fast-Track Comparison: GLP-1 Supplements Head-to-Head
Short on time or just have the attention span of a goldfish with ADHD? No judgment here! Check out our at-a-glance comparison table below. We’ve distilled hours of research into this neat little package – you’re welcome!
| Product | Price | Key Ingredients | Servings | Rating |
| Plus+Ultra GLP-1 Supplement | $29.99 | Berberine, Green Tea Extract, Turmeric | 60 capsules | ★★★★☆ (993) |
| Natnect GLP-1 Support | $31.90 | Green Tea Leaf, Beetroot Extract | 60 capsules | ★★★★☆ (989) |
| BioTrust GLP1 Elevate | $55.00 | Metabolaid, CQR-300, Polyphenol Blend | 60 capsules | ★★★★☆ (198) |
| Lemme GLP-1 Daily | $89.99 | Eriomin, Supresa, Morosil | 60 capsules | ★★★☆☆ (453) |
| WXW GLP-1 Supplement | $28.49 | Akkermansia Probiotic, Lactobacillus GG | 30 capsules | ★★★★☆ (29) |
1. Plus+Ultra GLP-1 Supplement: The Hunger Games Champion
If your stomach growls louder than your neighbor’s annoying dog, Plus+Ultra might just be your new best friend. This supplement has quickly become the darling of the GLP-1 world, and for good reason. It’s like having a tiny personal trainer living in your gut, constantly reminding you that maybe you don’t need that fourth slice of pizza after all.
What sets Plus+Ultra apart is its well-rounded formula. With a blend of Berberine Extract, Cinnamon, Turmeric, and Garcinia Cambogia, it’s like the Avengers of appetite control – each ingredient bringing its own superpower to the table. Users report feeling fuller faster and experiencing fewer cravings, especially for those late-night snack attacks that always seem to target carbs and sugar.
Pros
- ✅ Most affordable option at $29.99 ($0.50/count)
- ✅ Contains both probiotics and prebiotics for gut health
- ✅ Users report noticeable appetite suppression within weeks
- ✅ No reported jitters or energy crashes
- ✅ Made in the USA in a cGMP facility
Cons
- ❌ Capsules are on the larger side (chug that water!)
- ❌ Some users report mild digestive adjustment period
- ❌ Results may take 2-3 months for full effect
Specifications
- Form: Capsules
- Count: 60 capsules (30-day supply)
- Key Ingredients: Berberine Extract, Cinnamon, Turmeric, Garcinia Cambogia, Curcumin, Beta Glucan
- Recommended Dosage: 1 capsule, twice daily, 15-30 minutes before meals
- Rating: ★★★★☆ (993 reviews)
“I’ve tried everything short of stapling my mouth shut, and this is the first supplement that actually helps me feel satisfied with normal portions. Down 15 pounds in 3 months!” – Martha J.
2. Natnect GLP-1 Support: The Metabolism Whisperer
Natnect’s GLP-1 Support supplement comes in as our runner-up, and it’s giving our top pick a serious run for its money. If Plus+Ultra is the personal trainer of supplements, Natnect is more like the wise nutritionist who gently guides you toward better choices while boosting your metabolism behind the scenes.
This formula focuses heavily on metabolism support alongside appetite control. Users report not just eating less but also feeling more energetic throughout the day – without the jitters that caffeine-heavy supplements often bring. It’s like your metabolism got an oil change and a tune-up all at once. The green tea leaf extract and beetroot combination seems to be particularly effective for those struggling with afternoon energy slumps.
Pros
- ✅ Strong focus on both appetite control and energy
- ✅ Users report improved digestion and reduced bloating
- ✅ No artificial sweeteners or flavors
- ✅ Subscribe & Save option brings price down to $27.11
- ✅ Made in the USA
Cons
- ❌ Slightly more expensive than our top pick
- ❌ Some users report it works better when taken consistently for 3+ weeks
- ❌ A few reviews mention mild headaches during first week
Specifications
- Form: Capsules
- Count: 60 capsules (30-day supply)
- Key Ingredients: Green Tea Leaf Extract, Beetroot Extract, Metabolism-Supporting Herbs
- Recommended Dosage: 2 capsules once daily, 30 minutes before meals
- Rating: ★★★★☆ (989 reviews)
“Been using almost a month and I can feel the difference. I have more energy and overall feel better. I’ve lost about 10lbs this month. This supplement is easy to take and leaves no aftertaste.” – Stacey
3. BioTrust GLP1 Elevate: The Science-Backed Splurge
If supplements were cars, BioTrust GLP1 Elevate would be the luxury sedan with all the bells and whistles – and a price tag to match. This is definitely the “investment piece” of our lineup, but many users swear the results justify the splurge. BioTrust has built its reputation on science-backed formulations, and their GLP-1 supplement is no exception.
What makes BioTrust stand out is their use of patented ingredients like Metabolaid and CQR-300, which have actual clinical studies behind them. The company claims these can increase GLP-1 levels by over 50% – which is impressive if your wallet can handle the initial investment. Users report a significant reduction in “food noise” (you know, that constant mental chatter about what you might eat next) and improved satiety after meals.
Pros
- ✅ Contains clinically-studied ingredients with published research
- ✅ Users report 65% increase in feeling full after meals
- ✅ AMPK activation helps preserve muscle while losing fat
- ✅ Third-party tested for purity and potency
- ✅ Subscribe & Save brings price down to $46.75
Cons
- ❌ Most expensive option at $55.00 ($0.92/count)
- ❌ Mixed reviews on effectiveness (works great for some, not for others)
- ❌ Some users report it stopped working after 2 months
Specifications
- Form: Capsules
- Count: 60 capsules (30-day supply)
- Key Ingredients: Metabolaid, CQR-300, Polyphenol Blend (Green Tea, Pomegranate, Grape Extracts)
- Recommended Dosage: 2 capsules once daily before a meal
- Rating: ★★★★☆ (198 reviews)
“This supplement has been a game-changer for my daily routine, especially at work. What I love most is how it helps manage my appetite without any harsh side effects. Instead of experiencing those urgent ‘must eat now’ moments, I now have a much more balanced relationship with hunger.” – HERECOMESBOOMER
4. Lemme GLP-1 Daily: The Celebrity Contender
When celebrities enter the supplement game, I’m usually the first to roll my eyes – but Lemme GLP-1 Daily has some legitimate science behind its glamorous packaging. With the highest price point on our list, this is definitely positioning itself as the premium option for those who want their supplements to come with a side of star power.
The formula centers around three patented ingredients: Eriomin (a lemon bioflavonoid complex), Supresa (saffron extract), and Morosil (red orange extract). These aren’t just fancy names – they actually have clinical studies supporting their effectiveness for appetite control and metabolic support. The question is: are they worth nearly triple the price of our top pick? For some users, the answer is a resounding yes, while others report minimal results despite the hefty investment.
Pros
- ✅ Contains patented, clinically-studied ingredients
- ✅ Plant-based formula with no synthetic colors or flavors
- ✅ Gelatin-free capsules suitable for vegetarians
- ✅ Stylish packaging (if you care about that sort of thing)
- ✅ Subscribe & Save brings price down to $76.49
Cons
- ❌ Most expensive by far at $89.99 ($1.50/count)
- ❌ Polarizing reviews (works amazingly for some, not at all for others)
- ❌ Some users report digestive discomfort
- ❌ Lower overall rating than other options
Specifications
- Form: Capsules
- Count: 60 capsules (30-day supply)
- Key Ingredients: Eriomin lemon bioflavonoid complex, Supresa saffron extract, Morosil red orange extract
- Recommended Dosage: 2 capsules daily
- Rating: ★★★☆☆ (453 reviews)
“I won’t lie I bought this on a whim just hoping it would help curb my snack cravings and over eating and it did just that, it actually does help. Taking these I already see a small difference in my bloating but hoping it lasts as long as I exercise, stay hydrated along with eating 3 portioned meals a day.” – Samantha Ashley
5. WXW GLP-1 Supplement: The Probiotic Powerhouse
Rounding out our top five is WXW’s GLP-1 Supplement, which takes a different approach by focusing heavily on probiotics – specifically Akkermansia muciniphila and Lactobacillus GG. If you’ve been keeping up with gut health research, you might recognize Akkermansia as the “it girl” of the probiotic world, with studies linking it to metabolic health and weight management.
This supplement offers the fewest capsules (30 instead of 60), but the probiotic-centered approach seems to work well for many users, especially those who’ve struggled with digestive issues alongside weight management challenges. The theory is solid: healthy gut bacteria can influence GLP-1 production naturally. The downside? You’re getting half the capsules of our other picks, making this effectively more expensive per serving than it initially appears.
Pros
- ✅ Contains specialized probiotics linked to metabolic health
- ✅ Users report improved digestion alongside appetite control
- ✅ May help with bloating and gut discomfort
- ✅ Appears to work quickly for most users (within 1-2 weeks)
- ✅ Smaller capsule size makes it easier to swallow
Cons
- ❌ Only 30 capsules per bottle (15-day supply if taking 2 daily)
- ❌ Effectively more expensive per serving than it appears
- ❌ Fewer reviews than other options (newer to market)
- ❌ Some users report initial digestive adjustment period
Specifications
- Form: Capsules
- Count: 30 capsules (15-30 day supply depending on dosage)
- Key Ingredients: Akkermansia Muciniphila Probiotic, Lactobacillus GG
- Recommended Dosage: 1-2 capsules daily
- Rating: ★★★★☆ (29 reviews)
“I’ve tried several GLP-1 supplements, but this is the first one that didn’t cause digestive issues. In fact, it actually improved my digestion while helping control my appetite. The probiotic approach seems to work better for my body.” – Anonymous Reviewer
The No-Nonsense Buying Guide: How to Choose Your GLP-1 Supplement
Still scratching your head about which supplement to try? Don’t worry – you don’t need a PhD in Biochemistry to make a smart choice. Here’s what to consider before clicking that “Buy Now” button:
Ingredients Matter
Look for supplements with clinically-studied ingredients like Berberine, Green Tea Extract, Cinnamon, or specific probiotics like Akkermansia. Avoid products with proprietary blends that don’t disclose amounts – transparency is key!
Price vs. Value
The most expensive option isn’t always the best. Consider cost per serving rather than just bottle price. Our Editor’s Choice Plus+Ultra offers the best balance of quality ingredients and affordability at just $0.50 per capsule.
Reviews & Ratings
Pay attention to both the number and content of reviews. A product with 1,000+ reviews and a 4-star rating is generally more reliable than one with 20 reviews and 5 stars. Look for detailed reviews from verified purchasers.
Dosage & Convenience
Consider how many pills you’ll need to take and when. Some require taking capsules 30 minutes before meals, which might not fit your lifestyle. Be realistic about what routine you can maintain consistently.
Manufacturing Standards
Look for supplements made in cGMP (Current Good Manufacturing Practice) facilities and those that undergo third-party testing. This ensures you’re getting what’s on the label without contaminants.
Your Health Profile
Consider your own health needs and any conditions you have. If you have digestive issues, a probiotic-focused option might work better. If you’re sensitive to stimulants, avoid formulas heavy on caffeine or green tea extract.
Important Safety Note
GLP-1 supplements are not FDA-approved for weight loss and shouldn’t replace medical treatment. Always consult your healthcare provider before starting any supplement, especially if you have diabetes, are pregnant or nursing, or take medications. These supplements are not the same as prescription GLP-1 medications like Ozempic or Wegovy.
Frequently Asked Questions (No, Really, People Ask These A Lot)
Are GLP-1 supplements the same as Ozempic or Wegovy?
No, not even close. Prescription GLP-1 medications like Ozempic (semaglutide) are actual GLP-1 receptor agonists that mimic the hormone directly. Over-the-counter supplements aim to support your body’s natural GLP-1 production or create similar effects through other mechanisms. They’re generally less potent but also have fewer side effects and don’t require a prescription.
How long before I see results with GLP-1 supplements?
Most users report noticing changes in appetite within 2-4 weeks of consistent use. However, significant weight changes typically take 2-3 months of regular use combined with healthy diet and exercise. Remember, these aren’t magic pills – they’re tools to support your overall health efforts.
Can I take these supplements if I have diabetes?
You should absolutely consult your doctor before taking any supplement if you have diabetes. While GLP-1 can help with blood sugar regulation, these supplements could potentially interact with diabetes medications. Your healthcare provider needs to be part of this decision.
What side effects are common with GLP-1 supplements?
The most commonly reported side effects include mild digestive discomfort, gas, and changes in bowel movements, especially during the first 1-2 weeks. Some users also report headaches or mild nausea. These typically resolve as your body adjusts. If side effects persist or are severe, discontinue use and consult a healthcare professional.
Can I take more than the recommended dosage for faster results?
Please don’t. More is not better with supplements, and exceeding the recommended dosage increases your risk of side effects without necessarily improving results. Stick to the manufacturer’s guidelines and be patient – sustainable results take time.
The Bottom Line: Our Final Verdict on GLP-1 Supplements
After diving deep into the world of GLP-1 supplements (and experiencing some interesting digestive adventures along the way), we’ve come to some conclusions. While none of these supplements will give you the dramatic results of prescription GLP-1 medications, they can be valuable tools in your weight management toolkit when used consistently alongside healthy eating and regular exercise.
Our Editor’s Choice, Plus+Ultra GLP-1 Supplement, offers the best combination of effective ingredients, affordable price point, and positive user experiences. At just $29.99 for a month’s supply, it’s half the price of some competitors while delivering comparable or better results for most users. The inclusion of both prebiotics and probiotics also gives it an edge for overall gut health.
That said, everyone’s body responds differently to supplements. What works miracles for one person might do nothing for another. If you try one option without success after 2-3 months of consistent use, it might be worth experimenting with a different formulation – particularly one that takes a different approach (like the probiotic-focused WXW or the clinically-studied ingredients in BioTrust).
Ready to Take Control of Your Appetite?
Our Editor’s Choice Plus+Ultra GLP-1 Supplement offers the best balance of quality, effectiveness, and value. Why not give it a try?
Affiliate Disclosure: We may earn a commission if you purchase products through our links. This helps support our research and testing so we can continue bringing you honest reviews. Rest assured, our opinions are never influenced by compensation – we genuinely believe in the products we recommend.